This reports describes the CGIAR Reform Program of 2001. The CGIAR, which launched a change design and management initiative in October 2000, undertook a far-reaching program of reform in 2001, affecting its governance, programs, science, management, and potential impact. The reform program was based on the report of a Change Design and Management Team. Initial decisions on reform were reached at the CGIAR Mid-Term Meeting (the last of its kind) in May 2001. A second set of decisions, taken at the first CGIAR Annual General Meeting in October, fleshed out the initial decisions with operational details. The reform program: · limits meetings of the CGIAR to once-a-year, and provides for business to be conducted through a small Executive Council between annual meetings; · initiates the development of Challenge Programs that respond directly to major concerns on the global development agenda; · transforms the CGIAR Technical Advisory Committee (TAC) into a Science Council consisting of a few, high level science policy strategists; and · establishes a CGIAR System Office to facilitate coherence and cost effectiveness in system management.